Nine former and current Appalachian League players accepted invitations to participate in the 2025 MLB Draft Combine, which took place at Chase Field in Arizona on June 17-21. Those players had the opportunity to take part in drills and show off their skills in front of MLB Club personnel.

Former Appalachian League Manager Kevin Mahoney was named an assistant coach on the New York Mets Major League staff ahead of the 2025 MLB season.

The Appalachian League announced its 2025 schedule. The upcoming season will feature a 48-game regular season schedule, beginning with Opening Day on Thursday, June 5, and ending Wednesday, July 30.

Right-handed reliever Jordan Leasure made the Chicago White Sox's Opening Day roster. Leasure, an Elizabethton River Riders ‘21 alum, became the first Appalachian League player to reach the Major Leagues since the league rebranded as a summer collegiate league in 2021. The right-hander recorded a save in his Major League time with the White Sox.

Thirty-eight former Appalachian League players were selected in the 2024 MLB Draft, which took place July 14-16. The Minnesota Twins selected Kaelen Culpepper (BLU '22) with the No. 21 overall pick, the Appy League's highest selection ever. The Greeneville Flyboys led all Appy teams with 10 selections in the 20-round draft.